Communitas Foundation - JCM vol. 4, issue 1, 2011 -

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Contents:

ANIMAL MODELS OF HUMAN DISEASES AND THEIR SIGNIFICANCE FOR CLINICAL STUDIES OF NEW DRUGS

Review Article

Authors: I. Parvova¹, N. Danchev², E. Hristov³
¹Clinic of Rheumatology, Department of Internal Medicine, Medical University - Sofia
²Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University - Sofia
³Department of Internal Medicine, Medical University - Sofia

Contact details: I. Parvova, Clinic of Rheumatology, UMHAT „St. Ivan Rilski“, 13 Urvich St., 1612 Sofia, e-mail: ivaparvova@mail.bg, tel: +359 2 958 29 27

Keywords: animal models, extrapolation of data, allometric methods, pharmacokinetic/pharmacodynamic modelling (PK/PD modelling)

Abstract

Animal models are classical pharmacological models used as a mandatory element in preclinical (toxicological and pharmacological) studies of new drugs. Classical pharmacological studies involve the consecutive testing of new substances with human, animal, plant or chemical origin on isolated organs, followed by experiments on animals, mainly rats and mice, but also on higher animal species. The approaches using experimental animals are characterized by relatively high relevance and the data from the animal models are extrapolated to humans. In recent years, the replacement of animal testing and animal models with in-vitro models has been increasingly introduced into practice, but some studies still remain compulsory according to the modern manuals of pharmaco-toxicological preclinical study.

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