Communitas Foundation - JCM vol. 4, issue 1, 2011 -

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Contents:

SKIN BARRIER FUNCTION: MORPHOLOGICAL BASIS AND REGULATORY MECHANISMS

Review Article

Authors: R. Darlenski¹, J. Kazandjieva², N. Tsankov¹
¹Department of Dermatology and Venereology, Tokuda Hospital-Sofia
²Department of Dermatology and Venereology, Faculty of Medicine- Sofia

Contact details: R. Darlenski, 110 А Hipodruma res. distr., 1612 Sofia, Bulgaria, tel: +359 890 545599, e-mail: darlenski@abv.bg

Keywords: stratum corneum, transepidermal water loss, hydration, ceramides, keratin, filaggrin

Abstract

Skin covers the body and fulfils different functions: defensive, thermoregulatory, excretory, resorptive, metabolite and sensory. It accomplishes the protection of the mammalian organism against exogenous physical, chemical, and biological agents, as well as it sustains the organism’s homeostasis. Almost 90% of the skin barrier function resides in the stratum corneum. The major constituents of the barrier – lipid bilayers and corneocytes embedded in a cornified envelope interact to perform the multiple defensive functions. Herein the mechanisms for the regulation of the barrier homeostasis are discussed.

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